Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats

Bqoqu Li; Na Li; Shujuan Wang

doi:10.5455/njppp.2012.v2.i1.8

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Online Published: 01 Jan 2012

Natl J Physiol Pharm Pharmacol. 2012; 2(1): 52-57

doi: 10.5455/njppp.2012.v2.i1.8

Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats

Bqoqu Li, Na Li, Shujuan Wang.

Cited By:7

Abstract
Aim:Oridonin is a new anti-tumor drug candidate with promising antitumor activity. The aim of the present study is to investigate the single- and repeated-dose pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex in rats. Methods: Rats were given single- or multiple-dose (7 days) of injectable beta-cyclodextrin-oridonin inclusion complex (single-dose: 33 mg/m2, 99 mg/m2, 296 mg/m2; repeatede-dose: 99 mg/m2 calculated as oridonin) by intravenous injection. Plasma oridonin was analyzed by LC–ESI-MS. The main pharmacokinetics parameters were calculated and compared. Results: The PK data of single-dose injectable beta-cyclodextrin-oridonin inclusion complex in rats were best fit by a three-compartment model.The terminal elimination half-life (t1/2z) of oridonin ranged from 8.72±1.14 to 10.87±2.03h. AUC (0-t) and Cmax for oridonin showed statistically significant differences (p < 0.05) between singledose and repeated dose. Conclusion: Our study has led to the view that injectable beta-cyclodextrin-oridonin inclusion complex can increase the bioavailability of oridonin in rats and is suitable for once a day dosing. However, caution should be taken when injectable beta-cyclodextrin-oridonin inclusion complex is given by i.v. repeatedly.

Key words: Pharmacokinetics; Oridonin; Beta-cyclodextrin; rats

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Pubmed Style

Li B, Li N, Wang S. Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. Natl J Physiol Pharm Pharmacol. 2012; 2(1): 52-57. doi:10.5455/njppp.2012.v2.i1.8

Web Style

Li B, Li N, Wang S. Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. https://www.njppp.com/?mno=9541 [Access: June 22, 2026]. doi:10.5455/njppp.2012.v2.i1.8

AMA (American Medical Association) Style

Li B, Li N, Wang S. Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. Natl J Physiol Pharm Pharmacol. 2012; 2(1): 52-57. doi:10.5455/njppp.2012.v2.i1.8

Vancouver/ICMJE Style

Li B, Li N, Wang S. Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. Natl J Physiol Pharm Pharmacol. (2012), [cited June 22, 2026]; 2(1): 52-57. doi:10.5455/njppp.2012.v2.i1.8

Harvard Style

Li, B., Li, . N. & Wang, . S. (2012) Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. Natl J Physiol Pharm Pharmacol, 2 (1), 52-57. doi:10.5455/njppp.2012.v2.i1.8

Turabian Style

Li, Bqoqu, Na Li, and Shujuan Wang. 2012. Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 2 (1), 52-57. doi:10.5455/njppp.2012.v2.i1.8

Chicago Style

Li, Bqoqu, Na Li, and Shujuan Wang. "Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology 2 (2012), 52-57. doi:10.5455/njppp.2012.v2.i1.8

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Li, B., Li, . N. & Wang, . S. (2012) Pharmacokinetics of injectable beta-cyclodextrin-oridonin inclusion complex, a novel formulation of oridonin in Wistar rats. National Journal of Physiology, Pharmacy and Pharmacology, 2 (1), 52-57. doi:10.5455/njppp.2012.v2.i1.8

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