Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market

Anuradha S Joshi; Rajvi K Shah; Mona H Suthar; Unnati H Keharia

doi:10.5455/njppp.2021.11.12360202025122020

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Original Research
Online Published: 05 Jan 2021

Natl J Physiol Pharm Pharmacol. 2021; 11(2): 222-226

doi: 10.5455/njppp.2021.11.12360202025122020

Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market

Anuradha S Joshi, Rajvi K Shah, Mona H Suthar, Unnati H Keharia.

Cited By:3

Abstract
Background: Literature reports growing concern on ever-burgeoning list of irrational fixed dose combinations (FDCs) flooding the Indian market. Current study addresses availability and rationality of two most common group of FDC used clinically, that is, antimicrobial (AM) and antidiarrheal (AD).

Aim and Objective: Analysis of rationality of AM and AD, FDCs, and available in Indian market.

Materials and Methods: AM and AD, FDCs listed in Indian Drug Review 2017 and 2018, were analyzed using a validated eight- point criteria tool.

Results: Out of 138 FDCs, 102 (73.91%) belonged to AM group and 36 (26.08%) belonged to AD group. Out of 102 AM FDCs, 46 (45.09%) were rational and 56 (54.90%) were irrational. Out of 36 AD, FDCs, 10 (27.77%) were rational and 26 (72.22%) were irrational. Mean rationality score of AM and AD, FDCs, was (7.72 ± 0.33) and (7.5 ± 0.78), respectively.

Conclusion: Analysis reveals that a number of FDCs available in Indian market is irrational.

Key words: Fixed Dose Combination; Antimicrobial; Antidiarrheal; Irrational; Indian Market

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Pubmed Style

Joshi AS, Shah RK, Suthar MH, Keharia UH. Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. Natl J Physiol Pharm Pharmacol. 2021; 11(2): 222-226. doi:10.5455/njppp.2021.11.12360202025122020

Web Style

Joshi AS, Shah RK, Suthar MH, Keharia UH. Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. https://www.njppp.com/?mno=27726 [Access: June 22, 2026]. doi:10.5455/njppp.2021.11.12360202025122020

AMA (American Medical Association) Style

Joshi AS, Shah RK, Suthar MH, Keharia UH. Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. Natl J Physiol Pharm Pharmacol. 2021; 11(2): 222-226. doi:10.5455/njppp.2021.11.12360202025122020

Vancouver/ICMJE Style

Joshi AS, Shah RK, Suthar MH, Keharia UH. Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. Natl J Physiol Pharm Pharmacol. (2021), [cited June 22, 2026]; 11(2): 222-226. doi:10.5455/njppp.2021.11.12360202025122020

Harvard Style

Joshi, A. S., Shah, . R. K., Suthar, . M. H. & Keharia, . U. H. (2021) Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. Natl J Physiol Pharm Pharmacol, 11 (2), 222-226. doi:10.5455/njppp.2021.11.12360202025122020

Turabian Style

Joshi, Anuradha S, Rajvi K Shah, Mona H Suthar, and Unnati H Keharia. 2021. Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. National Journal of Physiology, Pharmacy and Pharmacology, 11 (2), 222-226. doi:10.5455/njppp.2021.11.12360202025122020

Chicago Style

Joshi, Anuradha S, Rajvi K Shah, Mona H Suthar, and Unnati H Keharia. "Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market." National Journal of Physiology, Pharmacy and Pharmacology 11 (2021), 222-226. doi:10.5455/njppp.2021.11.12360202025122020

MLA (The Modern Language Association) Style

Joshi, Anuradha S, Rajvi K Shah, Mona H Suthar, and Unnati H Keharia. "Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market." National Journal of Physiology, Pharmacy and Pharmacology 11.2 (2021), 222-226. Print. doi:10.5455/njppp.2021.11.12360202025122020

APA (American Psychological Association) Style

Joshi, A. S., Shah, . R. K., Suthar, . M. H. & Keharia, . U. H. (2021) Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market. National Journal of Physiology, Pharmacy and Pharmacology, 11 (2), 222-226. doi:10.5455/njppp.2021.11.12360202025122020

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