Abstract
Background: Diabetes mellitus (DM) is characterized by chronic hyperglycemia resulting in micro- and macro-vascular complications and is correlated with glycemic control and its duration. The undergoing pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Mean platelet volume (MPV) is a simple economical test in the monitoring of DM.

Aims and Objectives: This study aims to determine the activation of platelets in diabetes by measuring the MPV in non-diabetic and diabetic subjects, respectively and to find out the correlation of MPV with blood glucose level.

Materials and Methods: It was a cross-sectional study conducted on 70 previously diagnosed diabetic and 130 non-diabetic patients using convenient sampling in SCB Medical College, Odisha. Blood parameters such as body mass index (BMI), fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), and MPV were recorded from complete blood count and compared using independent sample t-test and Pearson correlation test.

Results: Mean age of the diabetic population was 53.7 ± 10.63 years. Positive correlation was found between MPV and BMI, FBS, PPBS, and HbA1c. The mean MPV in Group A was significantly lower than that of Group B.

Conclusion: MPV in Type 2 DM was significantly elevated and positively correlated to blood glucose level. Thus, strict glycemic control measures should be advised to patients with DM for halting the progression of complications in them.

Key words: Mean Platelet Volume; Diabetes Mellitus; Platelet Activation