Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits

Basem H Elesawy; Abd Al Rahman N Alghamdy; Ahmad El-Askary; Magdi M Salih

doi:10.5455/njppp.2016.6.07022016116

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Online Published: 25 May 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(3): 222-225

doi: 10.5455/njppp.2016.6.07022016116

Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits

Basem H Elesawy, Abd Al Rahman N Alghamdy, Ahmad El-askary, Magdi M Salih.

Cited By:5

Abstract
Background: Fluorosis is an endemic problem in many countries of the world.

Aims and Objectives: To see the effect of fluoride on the reproductive system and to see the role, if any, of vitamin D analog paricalcitol on it.

Materials and Methods: Sixty rabbits were divided into four equal groups. Group I was fed on standard diet, Group II vehicle-treated control, Group III on sodium fluoride (NaF) 20 mg/kg body weight, and Group IV on NaF + paricalcitol.

Result: In Group III (fed on NaF) significant decrease in sperm count (P < 0.001) and motility (P < 0.001) was seen compared with control. With vitamin D analog paricalcitol, there was a significant improvement in the sperm count (P < 0.001) and motility (P < 0.01). All of these significant changes were evident by histopathological evaluation of testicular biopsies.

Conclusion: Vitamin D analog paricalcitol treatment showed a significant improvement in reproductive functions.

Key words: Fluoride; Paricalcitol; Sperm; Histopathological Evaluation

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Pubmed Style

Elesawy BH, Alghamdy AARN, El-askary A, Salih MM. Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 222-225. doi:10.5455/njppp.2016.6.07022016116

Web Style

Elesawy BH, Alghamdy AARN, El-askary A, Salih MM. Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. https://www.njppp.com/?mno=218608 [Access: June 22, 2026]. doi:10.5455/njppp.2016.6.07022016116

AMA (American Medical Association) Style

Elesawy BH, Alghamdy AARN, El-askary A, Salih MM. Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 222-225. doi:10.5455/njppp.2016.6.07022016116

Vancouver/ICMJE Style

Elesawy BH, Alghamdy AARN, El-askary A, Salih MM. Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. Natl J Physiol Pharm Pharmacol. (2016), [cited June 22, 2026]; 6(3): 222-225. doi:10.5455/njppp.2016.6.07022016116

Harvard Style

Elesawy, B. H., Alghamdy, . A. A. R. N., El-askary, . A. & Salih, . M. M. (2016) Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. Natl J Physiol Pharm Pharmacol, 6 (3), 222-225. doi:10.5455/njppp.2016.6.07022016116

Turabian Style

Elesawy, Basem H, Abd Al Rahman N Alghamdy, Ahmad El-askary, and Magdi M Salih. 2016. Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 222-225. doi:10.5455/njppp.2016.6.07022016116

Chicago Style

Elesawy, Basem H, Abd Al Rahman N Alghamdy, Ahmad El-askary, and Magdi M Salih. "Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 222-225. doi:10.5455/njppp.2016.6.07022016116

MLA (The Modern Language Association) Style

Elesawy, Basem H, Abd Al Rahman N Alghamdy, Ahmad El-askary, and Magdi M Salih. "Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits." National Journal of Physiology, Pharmacy and Pharmacology 6.3 (2016), 222-225. Print. doi:10.5455/njppp.2016.6.07022016116

APA (American Psychological Association) Style

Elesawy, B. H., Alghamdy, . A. A. R. N., El-askary, . A. & Salih, . M. M. (2016) Evaluation of the effect of vitamin D on sodium fluorideinduced toxicity in reproductive functions of male rabbits. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 222-225. doi:10.5455/njppp.2016.6.07022016116

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