Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line

Vetriselvi Pandurangan; Safreen Shaikh Dawood Amanulla; Kumaresan Ramanathan

doi:10.5455/njppp.2016.6.08012016112

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Original Research
Online Published: 25 May 2016

Natl J Physiol Pharm Pharmacol. 2016; 6(3): 196-199

doi: 10.5455/njppp.2016.6.08012016112

Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line

Vetriselvi Pandurangan, Safreen Shaikh Dawood Amanulla, Kumaresan Ramanathan.

Cited By:21

Abstract
Background: Liver cancer is a deadly disease and devastating public health problem globally. Natural plant products with potent growth inhibition, and apoptosis induction properties are extensively being investigated for their cancer-preventive potential. Allium ascalonicum, being an important part of the diet across various countries, possesses numerous therapeutic effects and health-enhancing properties such as cancer prevention.

Aims and Objective: To investigate anticancer activity of dry and fresh A. ascalonicum.

Materials and Methods: The organic (ethanol) extracts of dry and fresh shallot bulb (A. ascalonicum) were prepared and tested for in vitro anticancer efficacy on liver cancer cell line HepG2 by MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Results: The results showed that both dry and fresh shallot extracts have anticancer potential with inhibitory concentration (IC50) of 50 µg/mL.

Conclusion: The plant investigated possesses remarkable anticancer activity. Further studies are essential for the isolation of lead molecules from the plant to treat liver cancer.

Key words: Allium ascalonicum; HepG2 Cell Line; MTT Assay; Anticancer Activity

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Pubmed Style

Pandurangan V, Amanulla SSD, Ramanathan K. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 196-199. doi:10.5455/njppp.2016.6.08012016112

Web Style

Pandurangan V, Amanulla SSD, Ramanathan K. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. https://www.njppp.com/?mno=214626 [Access: June 22, 2026]. doi:10.5455/njppp.2016.6.08012016112

AMA (American Medical Association) Style

Pandurangan V, Amanulla SSD, Ramanathan K. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol. 2016; 6(3): 196-199. doi:10.5455/njppp.2016.6.08012016112

Vancouver/ICMJE Style

Pandurangan V, Amanulla SSD, Ramanathan K. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol. (2016), [cited June 22, 2026]; 6(3): 196-199. doi:10.5455/njppp.2016.6.08012016112

Harvard Style

Pandurangan, V., Amanulla, . S. S. D. & Ramanathan, . K. (2016) Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. Natl J Physiol Pharm Pharmacol, 6 (3), 196-199. doi:10.5455/njppp.2016.6.08012016112

Turabian Style

Pandurangan, Vetriselvi, Safreen Shaikh Dawood Amanulla, and Kumaresan Ramanathan. 2016. Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 196-199. doi:10.5455/njppp.2016.6.08012016112

Chicago Style

Pandurangan, Vetriselvi, Safreen Shaikh Dawood Amanulla, and Kumaresan Ramanathan. "Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line." National Journal of Physiology, Pharmacy and Pharmacology 6 (2016), 196-199. doi:10.5455/njppp.2016.6.08012016112

MLA (The Modern Language Association) Style

Pandurangan, Vetriselvi, Safreen Shaikh Dawood Amanulla, and Kumaresan Ramanathan. "Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line." National Journal of Physiology, Pharmacy and Pharmacology 6.3 (2016), 196-199. Print. doi:10.5455/njppp.2016.6.08012016112

APA (American Psychological Association) Style

Pandurangan, V., Amanulla, . S. S. D. & Ramanathan, . K. (2016) Anticancer efficacy of dry and fresh Allium ascalonicum (shallot) against HepG2 cell line. National Journal of Physiology, Pharmacy and Pharmacology, 6 (3), 196-199. doi:10.5455/njppp.2016.6.08012016112

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