Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice

Shokhista Tashmukhamedova; Svetlana Polyarush; Tamara Aripova; Farrukh Riskulov; Lola Pulatova

doi:10.5455/njppp.2020.10.01007202002032020

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Original Research
Online Published: 11 Mar 2020

Natl J Physiol Pharm Pharmacol. 2020; 10(5): 363-367

doi: 10.5455/njppp.2020.10.01007202002032020

Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice

Shokhista Tashmukhamedova, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, Lola Pulatova.

Abstract
Background: To date, there is little evidence in the literature about the effects of synthetic cannabinoids spice and antidepressants on the mammalian immune system.

Aims and Objectives: The study of the formation of immunoglobulin (Ig)G and IgM class antibodies to synthetic cannabinoids spice and antidepressants for a comparative assessment of the role of the class of antibodies in the detection of dependence on psychotropic drugs.

Materials and Methods: Conjugates were obtained with four antidepressants: Faverin, carbamazepine, sertraline, and fluoxetine and two synthetic cannabinoids of the spice type AB-FUBINACA and ADB-CHMINACA in conjunction with the carrier protein-bovine serum albumin. The serological activity of synthesized conjugates based on the protein matrix was determined.

Results: Data were obtained on the determination of antibodies to the studied synthetic cannabinoids and antidepressants by enzyme-linked immunosorbent assay, and the immunoreactivity of mouse antibodies against heterologous haptens was established.

Conclusion: The article examines in detail the issues related to the comparative analysis of the formation of IgG and IgM antibodies to synthetic cannabinoids and antidepressants in mice in the experiment. It has been established that IgM antibodies play a significant role in the diagnosis of psychotropic substances.

Key words: Antibodies; Specific Immunoglobulin; Spice; Opiates; Barbiturates; Cannabinoids; L-Adrenaline; Dopamine Hydrochloride; Enzyme-linked Immunosorbent Assay; Haptens

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Pubmed Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. Natl J Physiol Pharm Pharmacol. 2020; 10(5): 363-367. doi:10.5455/njppp.2020.10.01007202002032020

Web Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. https://www.njppp.com/?mno=73645 [Access: November 01, 2025]. doi:10.5455/njppp.2020.10.01007202002032020

AMA (American Medical Association) Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. Natl J Physiol Pharm Pharmacol. 2020; 10(5): 363-367. doi:10.5455/njppp.2020.10.01007202002032020

Vancouver/ICMJE Style

Tashmukhamedova S, Polyarush S, Aripova T, Riskulov F, Pulatova L. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. Natl J Physiol Pharm Pharmacol. (2020), [cited November 01, 2025]; 10(5): 363-367. doi:10.5455/njppp.2020.10.01007202002032020

Harvard Style

Tashmukhamedova, S., Polyarush, . S., Aripova, . T., Riskulov, . F. & Pulatova, . L. (2020) Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. Natl J Physiol Pharm Pharmacol, 10 (5), 363-367. doi:10.5455/njppp.2020.10.01007202002032020

Turabian Style

Tashmukhamedova, Shokhista, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, and Lola Pulatova. 2020. Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. National Journal of Physiology, Pharmacy and Pharmacology, 10 (5), 363-367. doi:10.5455/njppp.2020.10.01007202002032020

Chicago Style

Tashmukhamedova, Shokhista, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, and Lola Pulatova. "Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice." National Journal of Physiology, Pharmacy and Pharmacology 10 (2020), 363-367. doi:10.5455/njppp.2020.10.01007202002032020

MLA (The Modern Language Association) Style

Tashmukhamedova, Shokhista, Svetlana Polyarush, Tamara Aripova, Farrukh Riskulov, and Lola Pulatova. "Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice." National Journal of Physiology, Pharmacy and Pharmacology 10.5 (2020), 363-367. Print. doi:10.5455/njppp.2020.10.01007202002032020

APA (American Psychological Association) Style

Tashmukhamedova, S., Polyarush, . S., Aripova, . T., Riskulov, . F. & Pulatova, . L. (2020) Study of the specifics of the formation of immunoglobulin G and immunoglobulin M antibodies to low molecular weight substances (synthetic cannabinoids and antidepressants) in laboratory mice. National Journal of Physiology, Pharmacy and Pharmacology, 10 (5), 363-367. doi:10.5455/njppp.2020.10.01007202002032020

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