Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital

Saubhagya Sindhu; Shaktibala Dutta; Mirza Atif Beg; Sanjeev Kumar Mittal; Sushobhan Das Gupta

doi:10.5455/njppp.2015.5.1601201519

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Original Research
Online Published: 02 Jul 2015

Natl J Physiol Pharm Pharmacol. 2015; 5(3): 207-211

doi: 10.5455/njppp.2015.5.1601201519

Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital

Saubhagya Sindhu, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, Sushobhan Das Gupta.

Cited By:6

Abstract
Background: The treatment of dry eyes has traditionally involved hydrating and lubricating the ocular surface, which include usage of artificial tear drops [carboxymethyl cellulose (CMC)]. Corticosteroids possess potential anti-inflammatory properties, thereby used in controlling inflammation in many organs. FDA has approved the prescription of topical corticosteroids for corticosteroid-responsive inflammatory conditions such as dry eye diseases.

Aims and Objective: To compare the effect of topical CMC alone or in combination with topical corticosteroid for the treatment of dry eye in a tertiary-care teaching hospital.

Materials and Methods: A total of 60 patients diagnosed with dry eye were enrolled for a study period of 1 year. Patients (n = 60) were stabilized on CMC for 2 weeks and there then divided into two groups: group I (n = 30), CMC; group II (n = 30), CMC + corticosteroid. The patients were followed up for 12 weeks. Diagnostic tests included Schirmers test and tear breakup time (TBUT) test. Quality of life was assessed by Ocular Surface Disease Index (OSDI). Analysis was done by t test; p <0.05 was considered significant.

Results: Schirmers values in groups I and II at 0 and 12 weeks were 7.8 ± 0.81 and 15.4 ± 0.62 (p < 0.0001) and 7.43 ± 0.42 and 17.53 ± 0.25 (p < 0.0001), respectively. TBUT values in groups I and II at 0 and 12 weeks were 4.93 ± 0.44 and 9.36 ± 0.35 (p < 0.0001) and 4.5 ± 0.38 and 10.43 ± 0.22 (p < 0.0001), respectively. OSDI score in groups I and II at 0 and 12 weeks were 87.64 ± 1.41 and 54.25 ± 1.09 (p < 0.0001) and 91.17 ± 1.13 and 53.55 ± 1.14 (p < 0.0001), respectively. At 12 weeks, intergroup comparison in Schirmers test (p < 0.05), TBUT test (p < 0.05), and OSDI score (p < 0.05) was done. Burning and stinging, photophobia, discharge, ocular infection, and increased intraocular pressure were among the common adverse effects seen.

Conclusion: Both groups showed significant improvement in Schirmers test, TBUT test, and OSDI score at the end of study. Intergroup comparison showed significant improvement in the group where corticosteroid was added. Adding corticosteroid ameliorated the symptoms rapidly but short-term use recommended because of adverse effects.

Key words: Dry Eye, Carboxymethyl Cellulose, Corticosteroid, Schirmers Test, Tear Breakup Time Test, Ocular Surface Disease Index

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Pubmed Style

Sindhu S, Dutta S, Beg MA, Mittal SK, Gupta SD. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 207-211. doi:10.5455/njppp.2015.5.1601201519

Web Style

Sindhu S, Dutta S, Beg MA, Mittal SK, Gupta SD. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. https://www.njppp.com/?mno=177694 [Access: November 02, 2025]. doi:10.5455/njppp.2015.5.1601201519

AMA (American Medical Association) Style

Sindhu S, Dutta S, Beg MA, Mittal SK, Gupta SD. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol. 2015; 5(3): 207-211. doi:10.5455/njppp.2015.5.1601201519

Vancouver/ICMJE Style

Sindhu S, Dutta S, Beg MA, Mittal SK, Gupta SD. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol. (2015), [cited November 02, 2025]; 5(3): 207-211. doi:10.5455/njppp.2015.5.1601201519

Harvard Style

Sindhu, S., Dutta, . S., Beg, . M. A., Mittal, . S. K. & Gupta, . S. D. (2015) Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. Natl J Physiol Pharm Pharmacol, 5 (3), 207-211. doi:10.5455/njppp.2015.5.1601201519

Turabian Style

Sindhu, Saubhagya, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, and Sushobhan Das Gupta. 2015. Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 207-211. doi:10.5455/njppp.2015.5.1601201519

Chicago Style

Sindhu, Saubhagya, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, and Sushobhan Das Gupta. "Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital." National Journal of Physiology, Pharmacy and Pharmacology 5 (2015), 207-211. doi:10.5455/njppp.2015.5.1601201519

MLA (The Modern Language Association) Style

Sindhu, Saubhagya, Shaktibala Dutta, Mirza Atif Beg, Sanjeev Kumar Mittal, and Sushobhan Das Gupta. "Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital." National Journal of Physiology, Pharmacy and Pharmacology 5.3 (2015), 207-211. Print. doi:10.5455/njppp.2015.5.1601201519

APA (American Psychological Association) Style

Sindhu, S., Dutta, . S., Beg, . M. A., Mittal, . S. K. & Gupta, . S. D. (2015) Comparative evaluation of topical carboxymethyl cellulose either alone or in combination with topical corticosteroid in the treatment of dry eye in a tertiary-care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology, 5 (3), 207-211. doi:10.5455/njppp.2015.5.1601201519

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